區(qū)域選擇性合成膦酸酯取代異苯并吡喃及異喹啉衍生物.pdf

1、南開大學(xué)碩士學(xué)位論文區(qū)域選擇性合成膦酸酯取代異苯并吡喃及異喹啉衍生物姓名：趙小娜申請學(xué)位級別：碩士專業(yè)：化學(xué)；有機(jī)化學(xué)指導(dǎo)教師：陳茹玉201105AbstractAbstractBothisoquinolineandisobenzofuranderivativesconstituteaveryimportantclassofheterocyclcsManynaturalproductscontainthestructuralunitso

2、fisoquinolineandisobenzofuranDuetomeirbroadrangeofpharmacologicalactivitiesandbioactivitiesmeirsynthesishasattractedmoreandmoreattentionThisdissertationdescribestheleadingsyntheticmethodsofisoquinolinederivativesandisobe

3、nzopyranderivativesOnthisbasis，WestudiedandsynthesizedisoquinolinederivativesandisobenzopyranylphosphonatederivativesrespectivelyTheexperimentsalesimpleandconvenientbothregioselectivityandyieldsofwhichaleexcellentTheirst

4、ructureswereconfirmedby1HNMR13CNMR31PNMRandHRMSSomecompoundswererecrystallizedandtlleirstructuresaledeterminedbyXraydiffractionanalysis3lPNMRwasusedtotracethereactionprocess，andthepossiblereactionmechanismisproposed1Regi

5、oselectivesynthesisofphosphonatesubstitutedisobenzopyranderivativesIaqR1_Me，Et；R2=H，CH3，Ph；R3=H，CH3；R4=Ph，PMeC6H4，PFC6H4，，1Bu2Re百oselectivesynthesisofisoquinolinederivativesIIakR1=H，CH3；R2=刀Pr，玎ButBu，cyclopropyl，Ph，PMeC6