光學(xué)純的胍催化下的不對(duì)稱Michael加成反應(yīng)的研究.pdf

1、復(fù)旦大學(xué)碩士學(xué)位論文光學(xué)純的胍催化下的不對(duì)稱Michael加成反應(yīng)的研究姓名：彭斌申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：有機(jī)化學(xué)指導(dǎo)教師：馬大為2000.6.1復(fù)旦大學(xué)碩士論文iiAbstractThisreportfocusedontheasymmetricMichaeladditionreactioncatalyzedbyenantiopurereagentssevennewenantiopureguandinesweredesigned、syn

2、thsizedandappliedtotheMichaeladditionreactionastheasymmetriccatalystsSomegoodresultswasobtained(a)EnantiopureguanidinecancatalyzetheMichaeladditionreactionbetweenglycinederivativesandacrylateestersTemperaturehasthestrong

3、effectontheyieldbutsinailoneOilthevalueofenantiomericexcessTHFwasfoundtobeamoresuitablesolvent98％ofyieldand545％ofeewereachievedwhen(R，R)一N，N’一Bis(1一(1一naphthyl)ethyl)guanidinewasusedastheenantiopurebase(b)Enantiopureguan

4、idinecallcatalyzetheMichaeladditionreactionbetweenglycinederivativesandNAcryloyl2一oxazolidonethebesteeof441％wereachievedwhen(R，R)一N，N’一Bis(1一(1naphthyl)ethyl)guanidinewasusedastheenantiopurebase(c)TheMichaeladductwasfoun

5、dtobeformedfromanthroneandN—methylmaleimideinthepresenceofcatalyticamountofvariousenantiopureguanidinesSolventandtemperatureexertedthestronginfluenceontheyieldandvalueofeeThebesteeof70％wasobservedinTHFat一200CKeyWord：asym