肝細胞癌癌旁組織中HBVDNA檢測對預(yù)測肝癌術(shù)后復(fù)發(fā)的意義.pdf

1、青島大學(xué)碩士學(xué)位論文肝細胞癌癌旁組織中HBVDNA檢測對預(yù)測肝癌術(shù)后復(fù)發(fā)的意義姓名：張斌申請學(xué)位級別：碩士專業(yè)：外科學(xué)（普外）指導(dǎo)教師：楊金鏞2002.4.10英文摘要THESIGNIFICANCEOFTHEHVEDNADE—TECTIONOFTHEADJACENTLIVERTIS—SUESINTHEHCCTOTHEFORCASTOFTHERECURRENCEAFTERHEPATECTOMYABSTRACTObjectiveToobse

2、rvetheeffectofHBV—DNAintherecurrenceofhepatocellularcarcinoma(HCC)MethodsPolymeraseChainReaction(PCR)wasusedtOdetectandautographicHBV—DNAinfreshperipheralbloodtumorandtheiradjacentlivertissuesoftheHCCpatientsWecontrasted

3、ourresultwiththatoffollowingobservationafterhepatectomyandanalysedtheresultsbydemographicmethodResultIn33patients，879％(29／33)withHBVhistory，positivedetectingrateofHBVDNAinperipheralbloodwas576％(19／33)InHCCtumortissuesthe

4、posi—tivedetectingrateofautographicHBV—DNAwas91％(3／33)，integratedHBVDNAwas7881％(26／33)InadjacentlivertissuesoftheHCCthepositivedetectingrateofautographicHBVDNAwas818％(27／33)。integratedHBVDNAwas758％(25／33)Therecurrentrate

5、inserumHBVDNApositvegroupwas632％(12／19)innega—tivegroupwas571％(8／14)，therewerenotstatisticallysignificant(P005)TherecurrentrateintumortissueautographicHBVDNApositvegroupwas667％(2／3)，innegativegroupwas60O％(18／30)，therewer

6、enotstatisticallysignificant(PO05)TherecurrentrateintumortissueintegratedHBVDNApositvegroupwas730％(19／26)，innegativegroupwas143％0／7)，therewerestatisticallysignificant(P005)TheresultsrevealmostHCCpatientshaveHBVhistorymos