涼血解毒法對(duì)實(shí)驗(yàn)性大鼠肝纖維化PDGF及ET干預(yù)作用的研究.pdf

1、南京中醫(yī)藥大學(xué)碩士學(xué)位論文涼血解毒法對(duì)實(shí)驗(yàn)性大鼠肝纖維化PDGF及ET干預(yù)作用的研究姓名：代海峰申請(qǐng)學(xué)位級(jí)別：碩士專(zhuān)業(yè)：中醫(yī)內(nèi)科學(xué)（肝膽?。┲笇?dǎo)教師：薛博瑜20080501ABSTRACTColdhearteddegassingtoexperimentalratsliverfibrosisPDGFand11rn●^‘E1interventiontunctionresearchAbstractThebodyofhepaticfibrosi

2、sisachromcliverinjuryandrepairresponses，butalsotoallkindsofchromcliverdiseasecirrhosisdevelopmentoftheinevitablestageCurrentlyrecognizedprimarilyinthepathogenesisofavarietyofcytokinesintheliver(cytokine，CK)participationf

3、romextracellularmatrix(Extracelluarmatrix，ECM)synthesisanddegradationofbalance，thatis，ofmorethandegradation，resultinginexcessivedepositionbytheECMHasbeenconfirmedthathepaticstellatecells(hepaticstellatecell，HSC)isthemajo

4、rECMproducelivercells，liverfibrosisHSCactivationisthecentrallinkVariousfactorSleadtoliverdamageliverinjury，andthencauselivercellnecrosisandinflammatorystimulation，avarietyofrelatedcellactivationCKHSC，agreatnumberofECMRec

5、entstudiesshowthattheECMcytokines，particularlycollagenproteinmetabolism，hasanimportantrole，andinmanycytokines，PDGFontheroleofliverfibrosisparticularconcernHasnowbeenconfirmedthattheliverfiberoftheoccurrenceanddevelopment

6、，andPDGFreceptorexpressionwassignificantlyhigherthanthatofnormaltissueitsactivity、析tllthedegreeofliverfibrosisandaddincreasedespeciallyintheexpressionofHSCanddegreeofliverfibrosisWassignificantlycorrelatedThismsearchtake

7、theChinesemedicinetheoryastheinstruction，throughtheclinicalreviewandtheexperimentalstudydiscussestheliverfibrosisthecauseofdiseasepathogenesis，thepathologytoevolve，totreattheFrancesidemedicineandthecurativeeffectmechanis

8、mThoughtthatthehepatitisliverfibrosisthecauseofdiseaseismainlypoisonousfortheexternaldiseasefactorshotanddampepidemicdisease，internalinjurydietorsentimentwillbeingoutofbalance；Thebasicpathogenesisfortheliverspleenkidneyd

9、amage，thevitalitytiesmutually；Thepathologyfactorhas，theheat，thepoison，thestasiswetandSOon；Andthestasishotwrestlesforitspathogenesiskeythetreatmentisdividedtheinitialperiodcoldhearteddisintoxicating，theclarificationishota

10、nddamp；Laterperiodadjuststhelivertotransportthespleenstraightensupremovingextravastedblood；ThetreatmentusesthemedicinehepatitisCpelletaftertheclinicalmanyyearapplicationobservation，thecurativeeffectisratheraccurateThisre