胃癌淋巴管生成及血管生成的特征及其與生物學(xué)行為的關(guān)系.pdf

1、青島大學(xué)碩士學(xué)位論文胃癌淋巴管生成及血管生成的特征及其與生物學(xué)行為的關(guān)系姓名：徐靜申請學(xué)位級別：碩士專業(yè)：病理與病理生理學(xué)指導(dǎo)教師：項鋒鋼20080531Thecharacterofiymphangiogenesisandangiogenesisinhumangastriccancerandtheirrelationshipwithbiologicalfeatures(Abstract)AIMS：Toinvestigatethedist

2、ributionpatterns，proliferativeactivity、theirrelationshipwithmetastasisandclinicopathologiccharactersoflymphaticmicrovesselsandmicrovesselsinpatientswithgastriccancerMETHODS：Thelymphaticmicrovesseldensity(LMVD)andmicroves

3、seldensity(MVD)of56casesofgastriccancersand12casesofnormalgastrictissueswereevaluatedbyimmunohistochemistryusingmonoclonalantibodyforpodoplaninandCD34Thel(i一67expressionofthelymphaticliningcellsandvascularliningcellswere

4、detectedatthesametimebydouble—stainingimmunohistochemistryRESULTS：1、Thelymphaticmicrovesselofnormalgastrictissuescanbeseenatmucosa、submucosa、muscularisandserosa，thenumberoflymphaticmicrovesselatsubmucosaisthemostThelymph

5、aticvesselsofintratumoralareaswerenotoftenseenandhadilldefinedLumina，whileatthesametime，theperitumorlymphaticvesselshadlargeandopenluminaTheLMVDatperitumorregions(1189395)wassignificantlyhigherthanthatofintratumoralareas

6、(583326)(t=101，P001)andnormalgastricsubmucosa(693132)(t’_752，P005)TheKi一67labelingindexofthelymphaticendothelialcellsatperitumorregionWassignificantlyhigherthanthatinnormalgastricsubmucosa(t=688，P005)andintratumoralparts

7、(t=638，P001)TheLMVDatperitumorregionssignificantlycorrelatedwithdifferentiationofgastriccancers、lymphaticinvolvementbytumorcellsandlymphnodesmetastasis(F=1496，t411、451；P005、001、001)TheperitumorKi67labelingindexofthelymph

8、aticliningcellsonlysignificantlycorrelatedwithlymphaticinvolvementbytumorcells(t_373，P001)2、Themicrovesselsofgastriccancersweretorturedandusuallyhadnoluminatheycouldbeseenbomatperitumorandintratumorregions，whileatthesame

9、time，themicrovesselsofnormaltissueshadcompleteluminaTheMVDatpedtumorregions(52894)wassignificantlyhigherthanthatofintratumoralareas(376985)andnormalgastrictissues(232319)(t847、687；P001、001)TheKi一67labelingindexofthevascu

10、larliningcellsatperitumorregion(002_001)wassignificantlyhigherthanthatofcorrespondingnormalgastrictissues(00030002)andintratumoralparts(0004o003)(t=364、1164；PO01、O01)TheperitumorMVDsignificantlycorrelatedwithdifferentiat