手性bronsted酸催化的吲哚與α，β不飽和三氟甲基酮的傅克烷基化反應(yīng)

1、天津大學(xué)碩士學(xué)位論文手性Bronsted酸催化的吲哚與α，β不飽和三氟甲基酮的傅克烷基化反應(yīng)姓名：裴增楷申請學(xué)位級別：碩士專業(yè)：有機(jī)化學(xué)指導(dǎo)教師：馬軍安20090501AbstractlndolesareaclassofHeterocyclewithimportantphysiologicalFunctionandpotentpharmacologicalactivityThedevelopmentofnewefficienLselec

2、tiveandgreensyntheticmethodsofthe3substitutedindolesderivativeshasattractedsustainedattentioninorganicsynthesis，duetotheirimportantbiologicalactivitiesandkeyroleasversatilebuildingbocksinthesynthesisofnaturalproductsandt

3、herapeuticagentTherefore，asymmetricFriedelCrafts(FC)alkylationhasbecomeapowerfulstrategyfortheconstructionofindolesarchitecturesDuetotheirspecialphysicchemicalandbiologicalproperties，trifluoromethylatedcompoundsfoundwide

4、applicationsinthefieldsofagrchemicals，pharmaceutical，dyesandfunctionalmateralsTrifluoromethylationiSthekeystepinthesynthesisoforganofluorinecompoundsBecauseoftheuniquecharacteristicsoffluorineTherewillbeasignificantimpro

5、vementinpropertiesforaromaticcompound，ifthinuoromethylgroupisintroducedintoitsstructuresUntillnOW，therehasalreadybeenanextensiveapplicationforthiskindofaromaticcompoundsInthispaperFriedel—CraftsAIky’iationofIndoleswith峨6

6、UnsaturatedTrifluoromethylKetonesproceededbywayofaBronstedacidcatalyzedWehadSynthesizedaseriesofnewtrifluoromethylatedchiralcompoundsandhadobtainedgoodyieldswithhighenantioselectivityInthisreaction，weexaminedcomprehensiv

7、eexperimentalfactors，suchascatalysts，solvents，temperaturesGoodresultswereobserved1nthebestconditionwecouldobtain99％yieldand88％eeThestructuresofthenewproductshadbeendeterminedbyIR1HNMlL13CNMRKeywordsIndoles，F(xiàn)riedei—Crafts