CRP與兒童阻塞性睡眠呼吸暫停低通氣綜合征.pdf

1、新疆醫(yī)科大學(xué)碩士學(xué)位論文CRP與兒童阻塞性睡眠呼吸暫停低通氣綜合征姓名：陳振江申請學(xué)位級別：碩士專業(yè)：兒科學(xué)指導(dǎo)教師：多力坤2009-04新疆醫(yī)科大學(xué)醫(yī)學(xué)碩士學(xué)位論文 新疆醫(yī)科大學(xué)醫(yī)學(xué)碩士學(xué)位論文 —2—Plasma C-Reactive protein in children with obstructive sleep apnea hypopnea syndrome Postgraduate student: Chen zhen

2、jiang Supervisor: Duo li kun vice professor Abstract Objective: To investigate the relationship of c-reactive protein (CRP)with obstructive sleep apnea hypopnea in children. Methods: Adopt to case control study, Accord

3、ing to the polysomnographic evaluations, consecutive children (n=67;age 3 to 15 years )with habitual snoring and symptoms were divided into three groups. They all completed a sleep apnea symptom questionaire . Samples fo

4、r plasma CRP level、 lipid profile and determinations were drawn the next morning . Results: Log plasma CRP levels were significantly higher in the moderate to severe group (obstructive apnea/ hypopnea index [AHI] of≥10

5、 ), compared with the mild OSAHS group (AHI of >5 and <10) and the control group (AHI of≤5 ). Significant positive correlations were found between log CRP levels and AHI (r =0.824) , whereas an inverse correlation

6、was found between the nadir arterial oxygen saturation and log CRP levels (r =-0.804). Moreover, 78.6% of the children with elevated log CRP levels reported excessive daytime sleepiness and/or learning problems, compared

7、 with 21.7% of children with normal log CRP levels . Conclusions: Children with OSAHS are associated with increasing levels of CRP, which is correlated with AHI, arterial oxygen saturation nadir. These changes were part